Wednesday, October 11, 2006


I'm here to share my excitement of biochemistry. Hopefully I can explain seemingly complex topics and processes in an understandable manner. I will also be focusing on Organic Chemistry, Molecular Biology as well as some topics concerning intelligent design and evolution.


Blogger William Bradford said...

Hi Doug. It's good to see your blog. I believe one of the more interesting aspects of biochemistry is the action of DNA helicases in splitting DNA strands. It is a basic and essential function yet one that results in positive supercoils in the DNA region ahead of the replication fork. Since accumulating positive supercoils impede the continuing unwinding of the double helix, a mechanism had to be in place to counter this in order to maintain function. This is interesting when analysed from a historic or evolutionary viewpoint. Enzymes known as topoisomerases with both nuclease and ligase capacities solve the problem but what type of selective, incremental process would lead to this? If topoisomerases were not present when the double helix was first separated then how could the strands be successfully unwound? If they were present then what causes led to their evolution and what were their precursor functions? Does the last question even make sense if DNA cannot be unwound?

6:25 PM  
Blogger William Bradford said...

News of your blog was posted in a Yahoo group by the moderator.

7:53 PM  

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